Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate
نویسندگان
چکیده
منابع مشابه
Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinases.
Phosphatidylinositol 4-phosphate (PI4P) regulates biosynthetic membrane traffic at multiple steps and differentially affects the surface delivery of apically and basolaterally destined proteins in polarized cells. Two phosphatidylinositol 4-kinases (PI4Ks) have been localized to the Golgi complex in mammalian cells, type III PI4Kbeta (PI4KIIIbeta) and type II PI4Kalpha (PI4KIIalpha). Here we re...
متن کاملPhosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis.
Professional phagocytic cells ingest microbial intruders by engulfing them into phagosomes, which subsequently mature into microbicidal phagolysosomes. Phagosome maturation requires sequential fusion of the phagosome with early endosomes, late endosomes, and lysosomes. Although various phosphoinositides (PIPs) have been detected on phagosomes, it remained unclear which PIPs actually govern phag...
متن کاملTrafficking of phosphatidylinositol by phosphatidylinositol transfer proteins.
PtdIns is synthesized at the endoplasmic reticulum and its intracellular distribution to other organelles can be facilitated by lipid transfer proteins [PITPs (phosphatidylinositol transfer proteins)]. In this review, I summarize the current understanding of how PITPs are regulated by phosphorylation, how can they dock to membranes to exchange their lipid cargo and how cells use PITPs in signal...
متن کاملRegulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins.
Introduction The endocytic pathway plays an important role in regulating the activities of signalling receptors. Experiments that block the clathrin-mediated internalization of epidermal growth factor receptors have shown that the relative strengths of various signalling pathways associated with the activated receptor are significantly altered as a consequence [l]. Recycling through the early e...
متن کاملAnalysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4 - phosphate and phosphatidylinositol 4 , 5 - bisphosphate
1. We have developed methods that yield estimates of the 32p content of each of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate, thus extending the information available from studies of the labelling of these lipids in intact cells or membrane preparations. The analyses are undertaken with the deacylated lipids. 2. Assay of the 5-pho...
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ژورنال
عنوان ژورنال: Science
سال: 2015
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aab1346